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PRMT7-AAV normalized mitochondrial fission and fusion dynamics after rmTBI in C57BL/6 J mice. Fission <t>(DRP1)</t> and fusion (OPA1) mitochondrial markers were assessed in the cortex and hippocampus. A) DRP1 protein levels were unchanged in the cortex, while B) OPA1 protein levels were decreased in the cortex at 7 days post rmTBI (blue bar) relative to SHAM (no virus – white bar), whereas PRMT7-AAV (green bar/black lines) increased OPA1 to nominal levels as compared to 7 days post-rmTBI mice + no virus (blue bars). C) DRP1 levels were lower in the hippocampus at 7 days post rmTBI (blue bar) relative to SHAM (white bar) and PRMT7-AAV enhanced DRP1 levels at 7 days post-rmTBI (green bar/black lines) relative 7 days post-rmTBI + no virus (blue bar). Lastly, D) OPA1 levels were reduced in 7 days rmTBI mice (blue bar) relative to SHAM (white bar) and enhanced to control levels with the administration of PRMT7-AAV (green bar/black lines). Proteins were measured by capillary-based immunoassay and normalized to total protein. Computer software generated pseudo-blots are presented below each of the corresponding protein graphs when applicable. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001; as evaluated by two-way ANOVA followed by Tukey’s post-hoc analysis.
Drp1, supplied by Novus Biologicals, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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drp1 antibody  (Novus Biologicals)
94
Novus Biologicals drp1 antibody
PRMT7-AAV normalized mitochondrial fission and fusion dynamics after rmTBI in C57BL/6 J mice. Fission <t>(DRP1)</t> and fusion (OPA1) mitochondrial markers were assessed in the cortex and hippocampus. A) DRP1 protein levels were unchanged in the cortex, while B) OPA1 protein levels were decreased in the cortex at 7 days post rmTBI (blue bar) relative to SHAM (no virus – white bar), whereas PRMT7-AAV (green bar/black lines) increased OPA1 to nominal levels as compared to 7 days post-rmTBI mice + no virus (blue bars). C) DRP1 levels were lower in the hippocampus at 7 days post rmTBI (blue bar) relative to SHAM (white bar) and PRMT7-AAV enhanced DRP1 levels at 7 days post-rmTBI (green bar/black lines) relative 7 days post-rmTBI + no virus (blue bar). Lastly, D) OPA1 levels were reduced in 7 days rmTBI mice (blue bar) relative to SHAM (white bar) and enhanced to control levels with the administration of PRMT7-AAV (green bar/black lines). Proteins were measured by capillary-based immunoassay and normalized to total protein. Computer software generated pseudo-blots are presented below each of the corresponding protein graphs when applicable. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001; as evaluated by two-way ANOVA followed by Tukey’s post-hoc analysis.
Drp1 Antibody, supplied by Novus Biologicals, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/drp1 antibody/product/Novus Biologicals
Average 94 stars, based on 1 article reviews
drp1 antibody - by Bioz Stars, 2026-02
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dynamin related protein 1  (Novus Biologicals)
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PRMT7-AAV normalized mitochondrial fission and fusion dynamics after rmTBI in C57BL/6 J mice. Fission <t>(DRP1)</t> and fusion (OPA1) mitochondrial markers were assessed in the cortex and hippocampus. A) DRP1 protein levels were unchanged in the cortex, while B) OPA1 protein levels were decreased in the cortex at 7 days post rmTBI (blue bar) relative to SHAM (no virus – white bar), whereas PRMT7-AAV (green bar/black lines) increased OPA1 to nominal levels as compared to 7 days post-rmTBI mice + no virus (blue bars). C) DRP1 levels were lower in the hippocampus at 7 days post rmTBI (blue bar) relative to SHAM (white bar) and PRMT7-AAV enhanced DRP1 levels at 7 days post-rmTBI (green bar/black lines) relative 7 days post-rmTBI + no virus (blue bar). Lastly, D) OPA1 levels were reduced in 7 days rmTBI mice (blue bar) relative to SHAM (white bar) and enhanced to control levels with the administration of PRMT7-AAV (green bar/black lines). Proteins were measured by capillary-based immunoassay and normalized to total protein. Computer software generated pseudo-blots are presented below each of the corresponding protein graphs when applicable. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001; as evaluated by two-way ANOVA followed by Tukey’s post-hoc analysis.
Dynamin Related Protein 1, supplied by Novus Biologicals, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/dynamin related protein 1/product/Novus Biologicals
Average 94 stars, based on 1 article reviews
dynamin related protein 1 - by Bioz Stars, 2026-02
94/100 stars
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PRMT7-AAV normalized mitochondrial fission and fusion dynamics after rmTBI in C57BL/6 J mice. Fission (DRP1) and fusion (OPA1) mitochondrial markers were assessed in the cortex and hippocampus. A) DRP1 protein levels were unchanged in the cortex, while B) OPA1 protein levels were decreased in the cortex at 7 days post rmTBI (blue bar) relative to SHAM (no virus – white bar), whereas PRMT7-AAV (green bar/black lines) increased OPA1 to nominal levels as compared to 7 days post-rmTBI mice + no virus (blue bars). C) DRP1 levels were lower in the hippocampus at 7 days post rmTBI (blue bar) relative to SHAM (white bar) and PRMT7-AAV enhanced DRP1 levels at 7 days post-rmTBI (green bar/black lines) relative 7 days post-rmTBI + no virus (blue bar). Lastly, D) OPA1 levels were reduced in 7 days rmTBI mice (blue bar) relative to SHAM (white bar) and enhanced to control levels with the administration of PRMT7-AAV (green bar/black lines). Proteins were measured by capillary-based immunoassay and normalized to total protein. Computer software generated pseudo-blots are presented below each of the corresponding protein graphs when applicable. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001; as evaluated by two-way ANOVA followed by Tukey’s post-hoc analysis.

Journal: Experimental neurology

Article Title: PRMT7 can prevent neurovascular uncoupling, blood-brain barrier permeability, and mitochondrial dysfunction in repetitive and mild traumatic brain injury

doi: 10.1016/j.expneurol.2023.114445

Figure Lengend Snippet: PRMT7-AAV normalized mitochondrial fission and fusion dynamics after rmTBI in C57BL/6 J mice. Fission (DRP1) and fusion (OPA1) mitochondrial markers were assessed in the cortex and hippocampus. A) DRP1 protein levels were unchanged in the cortex, while B) OPA1 protein levels were decreased in the cortex at 7 days post rmTBI (blue bar) relative to SHAM (no virus – white bar), whereas PRMT7-AAV (green bar/black lines) increased OPA1 to nominal levels as compared to 7 days post-rmTBI mice + no virus (blue bars). C) DRP1 levels were lower in the hippocampus at 7 days post rmTBI (blue bar) relative to SHAM (white bar) and PRMT7-AAV enhanced DRP1 levels at 7 days post-rmTBI (green bar/black lines) relative 7 days post-rmTBI + no virus (blue bar). Lastly, D) OPA1 levels were reduced in 7 days rmTBI mice (blue bar) relative to SHAM (white bar) and enhanced to control levels with the administration of PRMT7-AAV (green bar/black lines). Proteins were measured by capillary-based immunoassay and normalized to total protein. Computer software generated pseudo-blots are presented below each of the corresponding protein graphs when applicable. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001; as evaluated by two-way ANOVA followed by Tukey’s post-hoc analysis.

Article Snippet: Antibodies were diluted in the manufacturer provided antibody diluent (Protein Simple, Bio-techne, Minneapolis, MN) as follows: PRMT7 (1:100; D1K6R, Cell Signaling Technology, Danvers, MA), MMA (1:50; 8015S, Cell Signaling), DRP1 (1:10,000; NB110–55288, Novus Biologics), OPA1 (1:5000; NBP1–71656 (1E8–1D9) Novus Biologicals), ZO-1 (1:100; ab96587, Abcam), Occludin (1:100; 13409–1-AP, ProteinTech), GFAP (1:500; 3670S, Cell Signaling Technology), iba1 (1:50; 43733, Genetex).

Techniques: Virus, Software, Generated